The Benefits Are Clear
ACC’s PyroSmart NextGen ®
LAL Reagent
Conventional LAL Reagent
Competitor (rFC) Reagent
(rCR) Reagent
Comparison Table
2021
Year Technology Introduced
1977
2003
O No. Endpoint only
Kinetic Assay
Kinetic
P Kinetic
O No. rFC requires three reagents in a 1:4:5 ratio and a 10 min. pre-incubation step
Assay Setup
Single step
P Single step
reconstitution
reconstitution
O No. Fluorescent reader required
P Yes. Incubating plate or tube reader at 405 nm
Same Standard Plate Reader
Incubating plate or tube reader at 405 nm
O No. Based on Carcinoscorpius
P Yes. rCR is recombinant LAL
Derived From
LAL
Limulus Amebocyte Lysate (LAL)
or Tachypleus Amebocyte Lysate (CAL/TAL)
O No
P Yes
Multi-step Cascade Pathway
Yes
Endotoxin Specific
No
P Endotoxin Specific
P Endotoxin Specific
Sustainable Reagent (animal free)
No
P Horseshoe Crab Blood Free
P Horseshoe Crab Blood Free
Converting to PyroSmart NextGen ® Is Easy Switching to this sustainable alternative is easy because PyroSmart NextGen ® follows the same cascade pathway as traditional reagents. But don’t take our word for it – evaluate PyroSmart NextGen ® yourself on your existing absorbance readers. Follow our user-friendly Evaluation Protocol to determine if PyroSmart NextGen ® works in your laboratory and on your samples. Our experts will assist you every step of the way. If interested, simply contact an ACC Account Manager or Distributor today.
Keep Your Method. Make An Impact. • Same Instrument • Same Preparation Steps • Same Method The future of sustainable LAL testing has arrived with ACC’s PyroSmart NextGen ® recombinant LAL reagent. The new testing technology that delivers the best of traditional methods, combined with the benefits of sustainable recombinant Cascade Reagents (rCR). The future of LAL testing is bright!
Keep Your Method. Make An Impact.
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