Dissolution
Samples of the dissolution medium are taken at predefined time intervals to determine the percentage of dissolved drug present – typically using a UV/Vis Spectrophotometer or high-pressure liquid chromatography (HPLC). Dissolution of all but the most specialised oral pharmaceutical dosage forms can be tested with either the basket or paddle methods. Other techniques specified in the USP for dissolution testing include: Reciprocating Cylinder (Apparatus 3), Flow-Through Cell (Apparatus 4) and Reciprocating Holder (Apparatus 7). These are not routinely required except for highly specialised dosage forms.
Cylinder Ph. Eur. 2.9.4
Reciprocating Holder -
Vertical Diffusion Cell -
Special Immersion Cell -
- Special Suppository Basket -
USP App 6 <724>
USP App 7 <724>
USP <1724>
USP <1724>
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