Dissolution
Special Applications
Transdermal Patch Testing
Copley offers equipment for three different methods for the determination of the rate of drug release from transdermal patches.
1. Paddle Over Disk
2. Rotating Cylinder
3. Watch Glass / Patch
A modification of Method 2 (Paddle), the Paddle Over Disk technique is suitable for patches up to a maximum of 16 mm outside diameter. Using a suitable adhesive, the transdermal patch is simply, mounted on the disk, release side up.
A second larger version of the disk comprising a 90 mm diameter watch glass-patch-PTFE assembly is available for larger patches.
An alternative approach employs the same dissolution equipment as USP Method 1 (Ph. Eur 2.9.4 Method 3) with the basket replaced by a cylinder stirring element. In this method, the adhesive side of the transdermal patch is placed on an inert, porous cellulosic material. This is then attached to the exterior of the cylinder using a suitable adhesive. An extension piece is included in the kit for larger patches.
Transdermal Patch Testing
Cat. No. Description
1384
Standard disk according to USP Method 5
1384A
Watch Glass/patch/PTFE Assembly to USP Method 5 Hollister Medical Grade Adhesive (90 gm spray)
1385
1386
Cylinder Stirring Element including Extension (USP Method 6)
1386B
Height Gauge for Cylinder Stirring Element Cuprophan Flat Sheets, 128 x 345mm, Pack of 10
1387
37
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