Pharmaceutical Testing
Friability
Background: Friability Testing Friability is the tendency for a tablet to chip, crumble or break following compression and can occur due to shock or abrasion during subsequent manufacturing steps, packaging or shipping. Normally limited to uncoated tablets and surfaces, it is a tendency that can significantly erode tablet quality. Tablets need to be hard enough so that they do not break up in the bottle, to safeguard product stability and dose uniformity, but sufficiently friable to disintegrate in the gastrointestinal tract and release the active(s). Chapters Ph. Eur. 2.9.7 and USP <1216> describe reproducible and standardised methods and equipment to determine the friability of a tablet.
40
Powered by FlippingBook