Pharmaceutical Testing
Hardness
Background: Hardness Testing Together with friability, hardness (or breaking force) is a defining physical characteristic for a tablet. High hardness values may indicate for example, longer disintegration and dissolution times, compromising the speed of drug delivery. On the other hand, if hardness is too low, then friability may be also high, giving rise to poor product stability and compromised dose uniformity. By examining correlations between hardness, disintegration, dissolution and friability, a dosage form with optimum characteristics can be produced. Chapters Ph. Eur. 2.9.8 Resistance to Crushing of Tablets and USP Chapter <1217> Tablet Breaking Force describe standardised methods for the assessment of tablet hardness.
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